Lowe has been plagued by injuries over the past few years, most notably by a neck issue in 2014, and he has now been forced to call time on his career on medical grounds.
The 27-year-old centre, who represented England Under-20's during the Six Nations and Junior World Championships in 2009, says it is extremely disappointing to be bowing out of the game early but he must think about his future.
Speaking on retirement, Lowe said: "Every player is devastated when the decision to retire is taken out of their hands and it was the last thing that I wanted to hear when the diagnosis became clear.
"Despite every effort to get me back on the pitch, it was not to be, but I am immensely thankful to have had so much support from the Club and, in particular, from the medical staff.
"Rugby has given me so much; I have played and worked with so many great people, made so many friends, have some fantastic memories both on and off the field, for which I am truly grateful for."