The former UFC star will look to build on his impressive boxing debut when he takes on the former world champion in Saudi Arabia on March 8 and is expecting to come out on top in the bout.
Ngannou told The High Performance Podcast: "Nothing is impossible, right? We don't know the strength of Anthony Joshua but even though I don't believe he has that strength (to beat me), but we're going to find out. We're going to find out, and I think the reverse is going to happen. I'm going to be the one taking his soul."
The Cameroonian knocked Fury down in last October's fight but was beaten in a close decision loss, meaning that he is going to take the fight to Joshua from the outset to make sure that nobody else can decide the contest.
Ngannou said: "I won (the fight with Fury). Look at me now, look at my life, look at where I was when you think I lost. You think because some foolish judges make some decision, that changes anything in my life? My family that I was telling you about, they were sitting in the front row watching that fight.
"The dream that I was in since I was a kid, I was, that night, living that dream on top of the world. I was there. And for all the people that (have) been doubting me, I was there proving them wrong. For everybody that ever looked me down, I was there proving them wrong. I won everything."