The US golfer finished runner-up at the major for the second consecutive year but was disappointed that he didn't push champion Scottie Scheffler harder at Quail Hollow.
DeChambeau said: "I felt like I had the game to win this week and the golf course suited me pretty well. Missed a few putts coming down the stretch and got a little unlucky in this great game of golf. It kind of is what it is.
"I'm sure you heard me out there really baffled quite a bit. It was a good fight, good battle, take a lot from it. It's just burning a bigger fire in my belly."
The world number 10 added: "I'm baffled right now. Just felt like things didn't go my way this week. Drove it really well. I drove it as good as I can, as of right now, I gave myself a good chance. I just felt like a couple breaks went a different way."
DeChambeau has been in contention at both majors so far in 2025 but is irked that he has been unable to add to his two US Open triumphs.
He said: "Definitely had an opportunity to beat Rory [McIlroy at The Masters] and definitely had an opportunity to give Scottie a run this week. I was leading after 16 holes on the third round, but man, I just didn't get it done."
However, DeChambeau will use his scientific approach to refine his game ahead of the defence of his US Open crown at Oakmont next month.
The golfer said: "I've got to learn how to be a little more precise with the wind, not let the wind affect the ball as much. It's a tough task to do because I laid it so high and the ball just kind of moves it in the air. I've got to figure that out.
"I've got some tricks up my sleeve that I'm going to be working on and hopefully bring for the US Open, but I've got to get some equipment here soon."