After back-to-back 1-0 victories, the Red Devils suffered a disappointing performance at the weekend when losing 2-0 against West Ham United at the London Stadium, a result that leaves the 20-time English champions eighth in the Premier League.
Ole Gunnar Solskjaer finds himself under a degree of pressure after the slow start to the campaign and he will be aiming to give the fans something to cheer about in Wednesday's home clash against Rochdale.
The League One visitors are 17th in their division, six points above the relegation zone, and they are winless from their last four games in all competitions, losing three times and drawing once.
United are set to welcome back France international Paul Pogba, who has missed the club's last three games while he was absent for his country's Euro 2020 qualifying wins over Andorra and Albania last month.
The 26-year-old has recovered from the ankle issue that has kept him on the sidelines and Solskjaer confirmed the midfielder will play some part in the clash against The Dale.
"He'll probably get some minutes against Rochdale," the manager said at his press conference.
With a massive game at home to Arsenal to follow on Monday evening, Solskjaer is expected to ring the changes for Wednesday's encounter and offer some of the younger players an opportunity to shine.
Mason Greenwood is being tipped to lead the line, having opened his senior account in the 1-0 victory over Astana on Thursday, while Tahith Chong, playmaker Angel Gomes and Jesse Lingard could play as the three behind the striker.
Brazilian midfielder Fred is expected to be given a chance to impress, having struggled to establish himself since arriving in June 2018, while unsettled defender Marcos Rojo could also be handed some minutes.
Goalkeeper Sergio Romero is in line to take the gloves from Spanish star David de Gea, who recently penned a new contract, while full-back Diogo Dalot may also be named in the starting XI.