Leicester secured a 2-0 win at the Amex Stadium last weekend, with Seagulls captain Lewis Dunk missing the fixture after picking up his fifth yellow card of the season earlier in the month.
The centre-back will return for the clash against the Reds and talented young forward Aaron Connolly should feature too.
A groin injury had sidelined the Republic of Ireland striker, but the 19-year-old is fit again.
"It's a big boost to have Lewis Dunk back this weekend," Potter said at his pre-match press conference. "He's been great for us and anyone would miss their skipper, so we're delighted to be able to have him back for selection."
Brighton are set to be without Solly March and although Brazilian Bernardo featured for the Under-23s on Wednesday, he is still lacking match-fitness.
Former Ostersund manager Potter, along with his backroom staff, has signed a new contract which will run until the end of the 2024-25 campaign.
He only took over from Chris Hughton in the summer but has led Brighton to fine victories over Everton and Tottenham this season.
While happy, the 44-year-old knows there is a long way to go with the club five points above the bottom three and in 12th position after 13 games.
"We've still got a lot to do and from my perspective it's a little bit strange because we haven't done anything," Potter added. "I'm not one of those people that feels that secure by the length of the contract. I know the business we're in."
Liverpool will be missing key midfielder Fabinho through suspension.
The Brazilian could be out for even longer after appearing to pick up an ankle injury against Napoli in midweek and Saturday presents an opportunity for someone to stand up and stake a claim for his place.
Alex Oxlade-Chamberlain and James Milner are the two leading candidates for the position and Jurgen Klopp has a decision to make ahead of the weekend.