It was a bold choice for the German to make so many changes for the Merseyside derby, but it paid dividends as his much-rotated XI ran out 5-2 winners on the night.
Clean sheets still remain somewhat elusive, but it was a dominant performance with some exceptional moments going forward.
The Liverpool manager was in a buoyant mood after the win and struggled to pick out his personal highlights, keen to highlight a number of his players and their contributions.
"Oh, a lot of great football moments in that game," he told Premier League Productions.
"We spoke before about the five changes. I had to show respect to the boys for what they do in training. I speak a lot about the quality of the squad so have to show it. What they made of it was incredible. Divock's goals, Sadio's passes, Shaqiri's everything, Lallana was everywhere...
"So many good football moments but from time-to-time we were a bit rusty in defending. They were really direct and we had a lot of second ball situations."
Out went the suspended Alisson alongside Mohamed Salah, Roberto Firmino, Jordan Henderson and Alex Oxlade-Chamberlain and in came James Milner, Adam Lallana, Xherdan Shaqiri and Divock Origi as well as Adrian in goal.
Origi scored twice in the first half alongside Mane and Shaqiri, while Georginio Wijnaldum added a fifth late on.
The 5-2 win restored Liverpool's eight-point lead over Leicester City in second place, and 11 points over the champions Man City in third.
Klopp is now the second-fastest manager in Premier League history to reach 100 wins, having done so in 159 games.
Jose Mourinho was the fastest, managing it in 142.
"We knew these boys were good. We don't have a big squad because of injuries but young boys make impressions from behind too. We know the quality we have.
"They really push from behind so that's cool. That was the first game of a tough fixture list. We have to make changes and we will make changes.
"Naby Keita is the only one, who is in outstanding shape, who didn't play. I made five changes and was not brave enough to make six changes that is the only problem.
"I'm really pleased for them. I was not in doubt about it. The boys need to, when they have the chance, show it. Not for me really but for the public. I am really happy."