The national team's boss has responded after Raheem Sterling and Tyrone Mings voiced their opinions on the Black Lives Matter movement, while Jordan Henderson led an initiative to raise money for the NHS, and Marcus Rashford has helped feed children.
Speaking to BBC Radio 5 Live, the manager said he has "great admiration for the maturity they are showing".
He added: "We have group of players who understand they have an opportunity to make a difference - that their voices are heard - but they do that with some responsibility as well.
"If you believe in something strongly enough and have the opportunity to make a difference then that is something you have to grasp."
Southgate also encouraged a wider conversation to make the "huge steps" which are necessary to fight against racism across the globe.
He said: "I think yes, we should as a sport talk about opportunities for coaches and managers but there is also administration and many other areas of the game where we employ people in analysis departments and medical departments.
"We should have representation across all of those areas."