Mayweather quit boxing with a perfect undefeated record of 50-0 but Tyson doesn't think that qualifies him to come into the conversation, particularly when the likes of Sugar Ray Robinson and Julio Cesar Chavez have such impressive records of their own.
According to Give Me Sport, Tyson said: "Floyd’s a great fighter, don’t get me wrong, but he had 50 fights.
“Listen, Sugar Ray Robinson had 47 fights, he lost one, and he had 78 fights, a 78-fight winning streak with 60 knockouts.
“Don’t tell me about the greatest fighter with 50-0.
"He’s a great fighter no doubt about it, but 50-0.
"[Julio Cesar] Chavez had 90 (official record 107-6-3), he was fighting like eight times a year against whoever fought him, against whoever was in the rankings.”
Tyson returned to the ring after 15 years to take on Roy Jones Jr in an eight-round exhibition that ended in a draw.
And despite exhibition bouts getting a mixed reception from boxing fans, the man known as 'Iron Mike'.
He added: "This is bigger than championships, we are humanitarians, we are helping people.
"I'm happy I got this under the belt and I'll continue to go further and do more."