The American golfer will become just the seventh player to win all four majors should he triumph at Aronimink this week but insists that he doesn't see the tournament as any different from the other big tournaments.
Spieth said: "Just winning this tournament in general would be very special. The Ryder Cup's been such an important part of my life, and the PGA of America, having my instructor that I've been with for pretty much my whole career be a PGA of America professional, so there's many reasons.
"But obviously with having won the other three, that's the one that everyone focuses on. But when I'm out here, and certainly when I get out on the golf course, I've been in contention a couple of times in this tournament. It didn't feel any different than any other majors, so I wouldn't expect to if I get there this week."
Spieth must end a win drought on the PGA Tour dating back four years if he is to join the Grand Slam club and believes he can rediscover the form that saw him win three majors between 2015 and 2017.
He said: "I went on a run of feeling like I was contending or having a good chance of contending at every major for a number of years, and then it was periodic, and I feel like I'm close to being able to go back to doing that again. So I just want to give myself a chance."
Spieth feels that the underlying stats give him a chance of success if he can piece all aspects of his game together at the year's second major.
The world number 51 said: "If you look at the stats, yeah, it's a Whac-a-Mole situation because I have had weeks where I'm leading in putting, weeks where I'm leading in driving, weeks where I am leading in ballstriking, and then I just haven't been able to kind of put them all together."