The 25-year-old has not featured for Liverpool so far this term due to a back problem while he was also the subject of serious interest from Barcelona over the summer.
However, Coutinho came off the bench for both of Brazil's games over the international break and has been involved in first-team training back at Melwood this week.
Jurgen Klopp has hinted he may hold Coutinho back and name the former Inter Milan man on the bench.
Meanwhile, deadline-day signing Alex Oxlade-Chamberlain could be handed his debut following his £35 million switch from Arsenal.
England international full-back Nathaniel Clyne and midfielder Adam Lallana remain long-term absentees.