Caretaker boss David Unsworth will take charge of the Toffees for the first time following Ronald Koeman's sacking on Monday and has stated that he will not make wholesale changes for the last-16 encounter at Stamford Bridge.
However, the former Everton defender has said he will look to implement a more attacking style of play with the Merseysiders having struggled for goals this season.
Schneiderlin looks set to come straight back into central midfield having missed Sunday's loss to Arsenal with a knock and the Frenchman appears likely to replace Gueye, who serves a one-match ban after his sending off against the Gunners.
James McCarthy could also feature after he resumed training following a knee injury, but the game will come too soon for Ross Barkley.
Aaron Lennon, Seamus Coleman, Yannick Bolasie and Ramiro Funes Mori are long-term absentees.