The midfielder believes an invincible record this term will be too much to ask, despite City being the country's only unbeaten team in the top four divisions.
Saturday's 3-2 Premier League win at West Brom left them five points clear at the top of the Premier League ahead of Wednesday's Champions League trip to Napoli and the visit of Arsenal on Sunday.
But while De Bruyne is eager to tighten their grip at the top of the table, he feels going unbeaten is a tall order.
The 26-year-old said: "To go unbeaten? Well, it's very hard. I don't think it will be possible. The level of competition is so high, in every team. It's not like, with all respect, 10 or 15 years ago where you have a couple of teams that won't win against the top teams.
"Now, every game is hard and you need to be mentally there. And with the Champions League and all the cups, there will be a game where maybe we are a little bit less and maybe lose. But as long as it keeps going, it's good.
"Obviously, if you win a lot of games it's good for us. You keep maintaining pressure. Hopefully we can have two good games this week and go into the international break unbeaten and it will mean we put a lot of pressure on the rest."