Scotland have not won the prestigious competition since 1999, but they have been showing signs of progression over recent years and they may now be ready to challenge for the title.
Last year the Scots beat Ireland, Wales and Italy at Murrayfield, although they lost both their away fixtures and with three matches to come on their travels this year Watson knows they must up their game in those contests.
"This year we're got three away games so they'll be very tough. It's hard to go away to those places, to Wales, Dublin and Italy, and we're going to have some tough away games but we've got a very good squad and we're capable of getting those away wins," Watson was quoted as saying in The Scrum Magazine.
"We have to try and build around away wins and go to tricky places and take some scalps."
First up for Gregor Townsend's side in this year's competition is an away clash with Wales and the Scots will certainly face a tricky encounter as they have not won in Cardiff since 2002.
Watson believes the current Scotland squad are capable of winning at the Principality Stadium, however, particularly as they have already proven their credentials on the road following their impressive victory in Australia last summer.
The Edinburgh flanker added: "People keep telling us about the poor Cardiff record, but you know we have been improving, we went to Australia last summer and got a result and that has always been a tough place to win."