Hughton, an ex-Ireland international, acted as Brian Kerr's assistant a number of years ago before going on to have success in his own right at the Amex Stadium.
But Seagulls center-back Duffy said: "I don't know, I don't think the Brighton fans would be happy with me saying anything.
"You never know. Obviously Martin O'Neill's not going to be there forever, there are always different changes. But Chris is happy, I think, there.
"Chris isn't getting any younger either so there will come a time, for me, that if Martin ever did leave, it would be great for Chris to come in.
"He always asks about Ireland when I go back and talks about everything. He is really into it, so you never know in football.
"He is unbelievable, he is just getting better and better. He is getting a lot more respect in the game now for what he is doing and he fully deserves it.
"He has got Brighton to where they are now in a matter of three years. They are 12th in the Premier League so everything he gets he deserves."