Winger Kent came off with a hamstring injury during Saturday's win over St Mirren, a game Lafferty missed through injury and the pair are out again.
Rangers top Group G going into Thursday's match in Russia but it is a very tight group and bottom club Spartak could go top if they were to win by enough goals.
"It's an opportunity for someone else, certainly over the next couple of games, to come in and express themselves," said Gerrard.
"But there's no getting away from it that it's a big disappointment for myself and the team because Ryan has been in fantastic form and is a real threat for us. I'm sure other people are chomping at the bit for an opportunity.
"Kyle has still got an issue in his quad muscle, so unfortunately he hasn't made it here."