Pep Guardiola's men already have a mountain to climb it would seem after Sunday's shock 2-0 home defeat to Wolverhampton Wanderers, which handed the Kopites further daylight to City in second place.
The Citizens did memorably claw back a ten-point deficit on Jurgen Klopp's outfit last season, becoming the first team since Manchester United in 2007 to reclaim the title.
However, the champions do already look a very different animal this time around, with a makeshift rearguard seriously struggling to cope without the services of injured central defenders Aymeric Laporte and John Stones.
Winger Leroy Sane remains out until the new year after knee surgery, but Stones and key midfielder Kevin de Bruyne are both expected to return from injuries after the international break.
However, City's Brazilian shot-stopper Ederson does not believe the squad at the Etihad will be daunted by the pressure being exerted from Anfield.
The 26-year-old former Benfica man said: "It's never good news to be too far from the top of the table. But I think the Championship has hardly started, anything can happen. I think our team must be ready to face all the possible situations and always try to be on the top of the table or close.
"Personally, I don't feel the pressure. Of course, there is more pressure because it means that we have to win all the games now to catch up with them (Liverpool), so now I hope we can have that winning mentality to be able to win continuously."
Next up for the north-west giants is a trip to Selhurst Park to take on a Crystal Palace outfit that have enjoyed an excellent start to the campaign and sit just four places and two points behind City.