The Reds suffered a scare just before the international break when their star forward picked up an ankle injury in the 2-1 victory over Leicester City at Anfield.
Thankfully for Liverpool, the 27-year-old avoided serious injury, but was forced to limp off against the Foxes following a heavy challenge from Hamza Choudhury.
There were still fears that Salah could be forced to sit out the short trip to Old Trafford, but that now looks unlikely, and he is expected to take his place in Jurgen Klopp's side.
That is partly down to the fact that the Reds have put him on a special individual program during the international break to make sure he is fully fit and firing.
The news comes as a big boost to the Reds, who will need Salah on top form if they are to pick up all three points at Old Trafford and consolidate their place at the top of the Premier League table.
United have got off to a shocking start this season and look to be in turmoil, but with pride at stake, it still represents a tough task as Ole Gunnar Solskjaer's side will be desperate to get all three points.
Liverpool have also been boosted by the news that Joel Matip is fit again and is likely to take his place in the heart of the defence, while goalkeeper Alisson could also play.
The Brazilian has been on the sidelines since suffering a calf injury against Norwich back in August, but trained with the rest of the squad on Tuesday, and is expected to slot back in.
Liverpool are eight points clear at the top of the table, with Manchester City heading to Crystal Palace on Saturday.