The rivals meet in the Premier League on Thursday (12.05.22) in a match that will go a long way to deciding who qualifies for next season's Champions League and wants the supporters to create a similar noise to the match against Liverpool last weekend.
The Spurs boss said: "There is a big rivalry. The players know very well, and we want to give satisfaction to our fans, and we'll try to do our best.
"I hope to breathe a fantastic atmosphere, like the last game in Anfield.
"Our fans have to push us from the start until the end, in positive or negative moments, they have to stay with us and we have to try to overcome this obstacle together."
Despite the rivalry, Conte has urged his team to consider it as just another game as they bid to return to Europe's top competition.
He said: "I understand the importance [of the derby], and the rivalry between the two teams.
"But a derby is two games in a season, and a big team has to think that you have to win the derby, not because it's your rival, but because you get three points, and these points bring you [nearer] to winning something important at the end of the season.
"It's not only about being focused on beating your rival. Winning a derby has to be a way to reach an important target."