The goalkeeper announced earlier this week that she was bringing an end to her career with the Lionesses and the coach is saddened that the player won't be in her squad for Euro 2025 this summer.
Wiegman said before England's Nations League game against Portugal on Friday (30.05.25): "I'm really disappointed, I want her in my team.
"That must have been a hard decision for her, and so it is for us. Of course there have been conversations, that's between us, it's confidential.
"She has done such a great job for England, we've had an incredible journey. I really cherish that, that's where the disappointment comes from. It's emotional, because we have a relationship and we've had lots of highs, some lows too. It makes it hard. I'm sad.
"I try to connect with players in the best possible way. What you hope is that everyone feels good enough, fit enough and ready to come in, but that's not always the case.
"It's part of the increased demands on players and development of the game. We have to keep having conversations together."
England captain Leah Williamson also declared that she was "devastated" by Earps' decision to call time on her England career after 53 appearances.
She said: "I spoke to Mary. She's one of my closest friends in football. I'm devastated because I love her. I'm very sad that those memories aren't got to continue in an England shirt. If she thinks this is best for her I'll support her always.
"I know Mary, I know playing for her country meant everything to her. I care for Mary as a human first. To lose her leaves a gap there but we've had that before, players have to step up.
"I can't wait to see Mary's highlights reel because that's going to be great but for now we have a job to do."