The Liverpool skipper has led the Reds to the top of the table where they sit just two wins away from their first top flight title in 30 years, and while league bosses are hoping to resume the season next month, the midfielder knows it won't be the same behind closed doors.
Reflecting on the impact of the coronavirus pandemic, he told BBC Radio 5 Live: "Of course it would feel different because if you win any trophy and receive it without any fans there, it would be pretty strange.
"It is still not over. We still have work to do and we still need to perform at a high level right the way until the season finishes because we want to finish as strongly as we can to make sure it is a full season.
"After that, whether we win it or whatever, then [receiving] the trophy and the fans not being there... you just have to deal with it when it comes. Hopefully it does happen. We are still in a very good position."
Despite the unprecedented situation, Henderson is certain the club will have "some sort of celebration" with the fans once they are safely able to do so.
He added: "It will mean we have won the Premier League and we will all be very happy but then we can look to the future - and whenever fans are allowed back into the stadium, I am sure we will have some sort of celebration together."