The British tennis ace has pulled out of Roland Garros after struggling on clay this year and will now prioritise his grass-court game ahead of Wimbledon.
Murray hinted that he could miss the major after early exits in Monte Carlo and Madrid but did win his first title since 2019 by winning the ATP Challenger event in Aix-en-Provence.
However, further disappointments in Rome and Bordeaux have convinced him to sit out the tournament in Paris.
Speaking after his loss at the latter event, the former French Open finalist said: "It's not so much about [physical worries]. I trust that my body will be okay after what I did at the beginning of the year. I played back-to-back five-hour matches and did well physically in those matches. There's no reason why that should necessarily be any different here.
"It was just more to see where my game is at. It's just what the right thing is to prioritise at this stage in my career. I trust my body now but I'm aware that my best chance of having a deep run is more likely to happen at Wimbledon."
Murray had suggested that he wouldn't want to miss the French Open as he doesn't want to miss out on Grand Slams at this stage of his career.
The three-time major winner said: "I would like to play, just purely because I don’t know if I’ll get another opportunity to play [the French Open] again.
"But I also have ambitions of competing for Wimbledon titles and that sort of stuff. I know that sitting here today that probably doesn’t sound realistic, but I do believe that that’s a possibility. I obviously want to do the right thing there.
"I don’t know. It’s impossible to say what the right thing to do is, but obviously it’s a Grand Slam event. I would like the opportunity to play."