The Greek tennis star suffered a shock defeat to Dominic Stricker in the second round in New York and confessed that his display and preparation for the tournament were "not good enough".
Tsitsipas said: "By no means I'm supposed to put any blame on any people or any members of my team. Everything on court is under my control and under my talents, and the way I can play this sport are shown out on the court. If I'm not able to deliver, then I'm not supposed to be doing well.
"That's what happened this summer. I was not good enough to deliver and score good results. I won't blame it on anything.
"It's just a poor performance after Los Cabos. Had a tough transition to Toronto where I dealt with really bad jet lag that I never had such kind of experience on tour. Had a very difficult match against Gael (Monfils)."
The world number seven's hopes of winning a maiden Grand Slam are over for another year and Tsitispas declared that he only had himself to blame.
He said: "I have no reason to say anything. It was just pure competition. My opponent showed better tennis than I did. I want to congratulate him, because, you know, I consider myself a good player, and I don't want to be a person that can be beaten easily or I'm giving my opponents easy time on the court against me.
"I try to make it as hard as I can, and if it doesn't work, it doesn't work. I move on with my life. Hopefully I can get better in the future."