The Belgium international playmaker has been sidelined since mid-August when he suffered a knee ligament injury in training.
De Bruyne was expected to be out for three months because of the problem, which was seen as a big blow to the reigning Premier League champions given that he scored eight goals and provided 16 assists last term.
The 27-year-old's absence was felt in midweek as City slumped to a surprise 2-1 home defeat against Lyon in their opening Champions League group match, while he is poised to miss their next five league matches and European ties against Hoffenheim away and Shakhtar Donestk home and away.
However, De Bruyne has revealed that the Manchester derby at the Etihad Stadium on November 11 is his comeback target.
"I still need three, four, five weeks, but I'm getting there," De Bruyne said.
"Hopefully I can be back soon, help the team, and perform well. I'm hoping to be back after the next international break. I think I will be back for the derby."
City, currently third in the league standings with 13 points, visit Cardiff City on Saturday and punters can use their free bet to back them to bounce back from the Lyon defeat by picking up a comfortable win.